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Kinase Inhibitors
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View larger CDK461 Inhibitor
AT10735
CAS 2099128-41-1
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $238.00 | Total: $1,190.00 |
| 1 | 10 | $201.60 | Total: $2,016.00 |
| 1 | 25 | $170.80 | Total: $4,270.00 |
| 1 | 50 | $145.60 | Total: $7,280.00 |
| 1 | 100 | $126.00 | Total: $12,600.00 |
Data sheet
| Molecular Formula | C28H30F2N6 |
| Molecular Weight | 488.57 |
| CAS Numbers | 2099128-41-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC=1C2(C=3C(N1)=C(F)C=C(C3)C4=NC(NC5=CC=C(C=N5)C6CCN(C)CC6)=NC=C4F)CCCC2 |
| References | Yin L, et al. A highly potent CDK46 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy. Eur J Med Chem. 2018;144 1-28. |
More info
CDK461 Inhibitor (Crozbaciclib) is a type of CDK46 inhibitor (IC50s: 3 and 1 nM). CDK46 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer, which can block the process of breast cancer cell division and reproduction.