Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
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- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
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- Antifungal
- Antioxidant
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- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $88.40 | Total: $442.00 |
| 1 | 10 | $74.88 | Total: $748.80 |
| 1 | 25 | $63.44 | Total: $1,586.00 |
| 1 | 50 | $54.08 | Total: $2,704.00 |
| 1 | 100 | $46.80 | Total: $4,680.00 |
Overview
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo.
Chemical Properties
| Molecular Formula | C16H15F3N4 |
| Molecular Weight | 320.31 |
| CAS Numbers | 2101938-42-3 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | N[C@@H]1C[C@@H](CN(C1)c1ccc(C#N)c2ncccc12)C(F)(F)F |
Storage and Handling
0C Short Term, -20C Long Term
References
Jaromir Vlach, et al. Discovery of M5049 A Novel Selective TLR78 Inhibitor for Treatment of Autoimmunity. J Pharmacol Exp Ther. 2020 Dec 16;JPET-AR-2020-000275.