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Overview
Doxepin hydrochloride (Aponal) is a dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.
Chemical Properties
| Molecular Formula | C19H22ClNO |
| Molecular Weight | 315.837 |
| CAS Numbers | 1229-29-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cl.CN(C)CCC=C1c2ccccc2COc2ccccc12 |
Storage and Handling
0C Short Term, -20C Long Term
References
Ehlert FJ, et al. J Pharmacol Exp Ther. 1990 Apr;253[1] 13-9.