IMM-H007 (AMPK activator V1)

Novel lipid-lowering agent, acting as an AMPK activator, increasing ABCA1 protein expression and improving hepatic lipid metabolism and leukocyte trafficking in experimental hepatic steatosis

Core Functional Properties

1. AMPK Activation

• IMM-H007 activates AMP-activated protein kinase (AMPK), a key energy sensor enzyme that regulates cellular metabolism. PubMed

• Through AMPK activation, IMM-H007 influences lipid and glucose metabolism, reduces triglyceride accumulation, and improves cholesterol handling in the liver. PubMed

2. Lipid Metabolism & Atherosclerosis

• IMM-H007 improves cholesterol and triglyceride metabolism by activating AMPKα pathways, enhancing LDL receptor (LDLR) expression and promoting conversion of cholesterol to bile acids. PubMed

• It reduces hypercholesterolemia and atherosclerotic plaque formation in animal models. PubMed

3. Endothelial Function & Vascular Inflammation

• It suppresses vascular inflammation in atherosclerosis models, improving endothelial function. PubMed

• IMM-H007 enhances nitric oxide (NO) production by increasing AMPK-dependent eNOS activity, leading to better endothelial dilation. PubMed

• It also inhibits pro-inflammatory signaling (e.g., NF-κB and JNK/AP-1 pathways) to reduce inflammation in vascular tissues. PubMed+1

4. Cardiac Fibrosis & TGF-β1 Signaling

• IMM-H007 attenuates cardiac fibrosis in animal studies, partly via AMPK activation. PubMed

• It also directly interacts with transforming growth factor β1 (TGF-β1), reducing binding to its receptor and inhibiting downstream Smad2/3 signaling, a key driver of fibrotic gene expression. This effect can occur independently of AMPK. PubMed

5. Regulation of Inflammatory and Signaling Pathways

• IMM-H007 reduces endothelial inflammation through regulation of NF-κB and JNK/AP-1 signaling. PubMed

0°C (short term), -20°C (long term), desiccated