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RTA-408 (Omaveloxolone)
AOB87284
CAS: 1474034-05-3
Chemical Name: Omaveloxolone; Nrf1-activator-1; N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,7,8,8a,14a,14b-decahydropicen-4a-yl]-2,2-difluoropropanamide
1000 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $106.25 | Total: $531.25 |
| 1 | 10 | $90.00 | Total: $900.00 |
| 1 | 25 | $76.25 | Total: $1,906.25 |
| 1 | 50 | $65.00 | Total: $3,250.00 |
| 1 | 100 | $56.25 | Total: $5,625.00 |
Overview
Novel potent activator of the cytoprotective transcription factor Nrf2, being a robust mitigator of hematopoietic acute radiation syndrome
Chemical Properties
| Molecular Formula | C33H44F2N2O3 |
| Molecular Weight | 554.71 |
| CAS Numbers | 1474034-05-3 |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | N-((4aR,6aR,6bS,12aS,14aR,14bR)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide |
| InChl Key | RJCWBNBKOKFWNY-HGNIWHNWSA-N |
| InChl Code | InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22?,24+,29+,30-,31-,33-/m1/s1 |
| SMILES Code | CC(F)(F)C(N[C@]1(CCC(C)(C[C@@]1([C@]23[H])[H])C)CC[C@@]2(C)[C@]4(C)CCC5C(C)(C)C(C(C#N)=C[C@]5(C)C4=CC3=O)=O)=O |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
RTA408; RTA408; RTA-408. Omaveloxolone
References
1) Alexeev V, Lash E, Aguillard A, Corsini L, Bitterman A, Ward K, Dicker AP, Linnenbach A, Rodeck U. Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound. Mol Cancer Ther. 2014 Dec;13(12):2968-77. doi: 10.1158/1535-7163.MCT-14-0354. Epub 2014 Nov 14. PubMed PMID: 25398830; PubMed Central PMCID: PMC4258451.