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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $34.85 | Total: $174.25 |
| 1 | 10 | $29.52 | Total: $295.20 |
| 1 | 25 | $25.01 | Total: $625.25 |
| 1 | 50 | $21.32 | Total: $1,066.00 |
| 1 | 100 | $18.45 | Total: $1,845.00 |
Overview
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of ?-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-? peptides, binds directly to ?-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 ?M, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.
Chemical Properties
| Molecular Formula | C36H45N5O8S |
| Molecular Weight | 707.84 |
| CAS Numbers | 24730-10-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CS(O)(=O)=O.[H][C@@]12CCCN1C(=O)[C@H](Cc1ccccc1)N1C(=O)[C@](NC(=O)[C@H]3CN(C)[C@]4([H])Cc5c[nH]c6cccc(c56)[C@@]4([H])C3)(O[C@@]21O)C(C)C |
Storage and Handling
0C Short Term, -20C Long Term
References
Lei X, et al. The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-? peptides. Sci Rep. 2015 Nov 16;5 16541.