Categories
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $253.30 | Total: $1,266.50 |
| 1 | 10 | $214.56 | Total: $2,145.60 |
| 1 | 25 | $181.78 | Total: $4,544.50 |
| 1 | 50 | $154.96 | Total: $7,748.00 |
| 1 | 100 | $134.10 | Total: $13,410.01 |
Overview
A?-IN-1 is a novel, potent and orally active ?-secretase modulator (GSM). A?-IN-1 potently reduced A?42 levels with an IC 50 value of 0.091 ?M in cultured cells without inhibiting CYP3A4. A?-IN-1 shows a sustained pharmacokinetic profile.
Chemical Properties
| Molecular Formula | C35H49N |
| Molecular Weight | 483.77 |
| CAS Numbers | 2766509-32-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C=5C(CC2)=NC=6C(C5C)=CC=CC6)[H])[H] |
Storage and Handling
0C Short Term, -20C Long Term
References
Albuquerque HMT, et al. Steroid-Quinoline Hybrids for Disruption and Reversion of Protein Aggregation Processes. ACS Med Chem Lett. 2022;13[3] 443-448.