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Overview
Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA. This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria. Primaquine is active against late hepatic stages (hypnozoites, schizonts).
Chemical Properties
| Molecular Formula | C15H21N3O |
| Molecular Weight | 455.34 |
| CAS Numbers | 63-45-6 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CC(CCCN)Nc1c2c(cc(c1)OC)cccn2.OP(=O)(O)O.OP(=O)(O)O |
Storage and Handling
0C Short Term, -20C Long Term
References
Vale N, et al. Eur J Med Chem, 2009, 44[3], 937-953.