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Overview
Carbendazim (Mercarzole) is a broad-spectrum benzimidazole antifungal with potential antimitotic and antineoplastic activities. Although the exact mechanism of action is unclear, carbendazim appears to binds to an unspecified site on tubulin and suppresses microtubule assembly dynamic. This results in cell cycle arrest at the G2M phase and an induction of apoptosis.
Chemical Properties
| Molecular Formula | C9H9N3O2 |
| Molecular Weight | 191.19 |
| CAS Numbers | 10605-21-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | |
| InChl Key | |
| InChl Code | |
| SMILES Code | COC(=O)NC1=NC2=CC=CC=C2N1 |
Storage and Handling
0C Short Term, -20C Long Term
Synonyms
References
Jiang J, et al. Toxicol In Vitro. 2015 Oct;29[7] 1473-81.