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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $129.20 | Total: $646.00 |
| 1 | 10 | $109.44 | Total: $1,094.40 |
| 1 | 25 | $92.72 | Total: $2,318.00 |
| 1 | 50 | $79.04 | Total: $3,952.00 |
| 1 | 100 | $68.40 | Total: $6,840.00 |
Overview
APX2039 is an orally active fungal Gwt1 enzyme inhibitor and a prodrug of the novel Gwt2096 inhibitor APX1.APX2039 exhibits potent anti-Kryptococcal activity against C. neoformans and C. gattii.APX2039 exhibits potent antifungal activity and blocks the localization of GPI (glycosylphosphatidylinositol) anchored cell wall mannoproteins. APX2039 has potent antifungal activity and blocks the localization of GPI (glycosylphosphatidylinositol)-anchored cell wall mannoproteins.APX2039 can be used to study cryptococcal meningitis (CM).
Chemical Properties
| Molecular Formula | C20H15FN4O2 |
| Molecular Weight | 362.36 |
| CAS Numbers | 2342606-49-7 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Nc1ncccc1-c1cc(Cc2ccc(Oc3cccc(F)n3)cc2)no1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Karen J Shaw, et al. 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis. Open Forum Infect Dis. 2020 Dec 31.