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Bis-T-23 View larger

Bis-T-23 (Ryngo 1-23)

AOB5869

CAS No: 171674-76-3

Chemical Name: 1,3-Bis(2-Cyano-3-(3,4,5-trihydroxy-phenyl)-acrylamino)propane

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $67.15 Total: $335.75
110 $56.88 Total: $568.80
125 $48.19 Total: $1,204.75
150 $41.08 Total: $2,054.00
1100 $35.55 Total: $3,555.00

Data sheet

Molecular FormulaC23H20N4O8
Molecular Weight480.43
CAS Numbers171674-76-3
SolubilityDMSO
Purity98% by HPLC
SynonymRyngo-1-23; Ryngo 123; Ryngo 1 23; Bis-T-23; Bis T-23; Bis T 23; Bis-T 23; AG 1717; AG1717; AG-1717
IUPAC/Chemical Name (2E,2'E)-N,N'-(propane-1,3-diyl)bis(2-cyano-3-(3,4,5-trihydroxyphenyl)acrylamide)
InChl KeyKey: AAPVOSBVTLGGOU-VHUAAIQRSA-N
InChl CodeInChI=1S/C23H20N4O8/c24-10-14(4-12-6-16(28)20(32)17(29)7-12)22(34)26-2-1-3-27-23(35)15(11-25)5-13-8-18(30)21(33)19(31)9-13/h4-9,28-33H,1-3H2,(H,26,34)(H,27,35)/b14-4+,15-5+
SMILES CodeO=C(NCCCNC(/C(C#N)=C/C1=CC(O)=C(O)C(O)=C1)=O)/C(C#N)=C/C2=CC(O)=C(O)C(O)=C2
References1) Sever S, Schiffer M. Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases. Kidney Int. 2018 Jun;93(6):1298-1307. doi: 10.1016/j.kint.2017.12.028. Epub 2018 Apr 17. Review. PubMed PMID: 29678354; PubMed Central PMCID: PMC5967993.

2) Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H. O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes. Nephrol Dial Transplant. 2017 Sep 1;32(9):1477-1487. doi: 10.1093/ndt/gfw463. PubMed PMID: 28339907.

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Promoter of actin-dependent dynamin oligomerization, increasing actin polymerization in injured podocytes