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Overview
Methyldopa hydrate (MK-351 hydrate) is a DOPA decarboxylase inhibitor and indirect ?2-adrenergic receptor agonist used to treat hypertension. It inhibits the sympathetic nervous system, decreases production of dopamine, norepinephrine, and epinephrine, and exhibits NO-dependent sedative activity.
Chemical Properties
| Molecular Formula | C10H13NO4 |
| Molecular Weight | 238.24 |
| CAS Numbers | 41372-08-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O |
Storage and Handling
0C Short Term, -20C Long Term
References
Baila M R , Cintas J A . [The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension][J]. El D