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> G Protein-Coupled Receptor Ligands>Apelin Receptor>ELA-14(human) acetate

Apelin Receptor

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ELA-14(human) acetate

ATP1923L1

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$81.00

$81.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $68.85 Total: $344.25
110 $58.32 Total: $583.20
125 $49.41 Total: $1,235.25
150 $42.12 Total: $2,106.00
1100 $36.45 Total: $3,645.00

Data sheet

Molecular FormulaC77H123N25O19S2
Molecular Weight1767.09
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCC(C)C[C@@H](C(N[C@@H](Cc1c[nH]cn1)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N(CCC1)[C@@H]1C(N[C@@H](Cc1ccccc1)C(N(CCC1)[C@@H]1C(O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CCC1)N1C([C@H](CCSC)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CC1)NC1=O)=O)=O)=O)=O)=O)=O.CC(O)=O
ReferencesAlexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59[7] 2962-72.

More info

ELA-14(human) acetate is a fragment of ELA that binds to APJ, activates the G?i1 and ?-arrestin-2 signaling pathways, and induces receptor internalization similarly to its parent endogenous peptide.