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CPTH6 HBr View larger

CPTH6 HBr

AOB0254

CAS No: 2321332-57-2; 1099614-81-9 (free base)

 

Chemical Name: 3-Methylcyclopentylidene-[4-(4'-chlorophenyl)thiazol-2-yl]hydrazone Hydrobromide

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QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $22.95 Total: $114.75
110 $19.44 Total: $194.40
125 $16.47 Total: $411.75
150 $14.04 Total: $702.00
1100 $12.15 Total: $1,215.00

Data sheet

Molecular FormulaC15H17BrClN3S
Molecular Weight386.74
CAS Numbers2321332-57-2; 1099614-81-9 (free base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMF: 25 mg/ml DMSO: 25 mg/ml DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml Ethanol: 0.5 mg/ml
Purity98% by HPLC
IUPAC/Chemical Name3-methyl-cyclopentanone, 2-[4-(4-chlorophenyl)-2-thiazolyl]hydrazone, monohydrobromide
InChl KeyFTEQRZOKSCOLKS-PUBYZPQMSA-N
InChl CodeInChI=1S/C15H16ClN3S.BrH/c1-10-2-7-13(8-10)18-19-15-17-14(9-20-15)11-3-5-12(16)6-4-11;/h3-6,9-10H,2,7-8H2,1H3,(H,17,19);1H/b18-13+;
SMILES CodeClC(C=C1)=CC=C1C2=CSC(N/N=C3CCC(C)C3)=N2.Br
References1) Trisciuoglio, D., Ragazzoni, Y., Pelosi, A., et al. CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells. Clin. Cancer Res. 18(2), 475-486 (2012).

2) Ragazzoni, Y., Desideri, M., Gabellini, C., et al. The thiazole derivative CPTH6 impairs autophagy. Cell Death Dis. 4, e524 (2013).

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Novel inducer of histone hypoacetylation and apoptosis in human leukemia cell, impairing autophagy