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Nifedipine

AT1146

CAS 21829-25-4

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$38.00

$38.00 per 500 mg

Data sheet

Molecular FormulaC17H18N2O6
Molecular Weight346.33
CAS Numbers21829-25-4
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCOC(=O)C1=C(C)NC(C)=C(C1C1=C(C=CC=C1)[N+]([O-])=O)C(=O)OC
ReferencesDing Y, et al. J Pharmacol Exp Ther,2000, 292[2], 606-609.

More info

Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.