Array
(
)
1
> Pathway Inhibitors>Cell Inhibition>E6446

Cell Inhibition

E6446 View larger

E6446

AOB8498

CAS nO: 1219925-73-1

 

Chemical Name: 6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole

More details

987 Items

Molarity Calculation Cart®

HOW TO ORDER

$59.00

$59.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $50.15 Total: $250.75
110 $42.48 Total: $424.80
125 $35.99 Total: $899.75
150 $30.68 Total: $1,534.00
1100 $26.55 Total: $2,655.00

Data sheet

Molecular FormulaC27H35N3O3
Molecular Weight449.59
CAS Numbers1219925-73-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymE6446; E 6446; E-6446
IUPAC/Chemical Name6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole
InChl KeyYMYJXFUPMPMETB-UHFFFAOYSA-N
InChl CodeInChI=1S/C27H35N3O3/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30/h7-12,21H,1-6,13-20H2
SMILES CodeC1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1
References1) Dias AA, Silva CO, Santos JP, Batista-Silva LR, Acosta CC, Fontes AN, Pinheiro RO, Lara FA, Machado AM, Nery JA, Sarno EN, Pereira GM, Pessolani MC. DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum. J Immunol. 2016 Sep 1;197(5):1905-13.

2) Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

More info

Novel antagonist of nucleic acid-sensing TLRs, potently suppressing DNA stimulation of HEK:TLR9 cells

Customers who bought this product also bought: