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E6446
AOB8498
CAS nO: 1219925-73-1
Chemical Name: 6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $26.55 | Total: $2,655.00 |
| 1 | 50 | $30.68 | Total: $1,534.00 |
| 1 | 25 | $35.99 | Total: $899.75 |
| 1 | 10 | $42.48 | Total: $424.80 |
| 1 | 5 | $50.15 | Total: $250.75 |
Data sheet
| Molecular Formula | C27H35N3O3 |
| Molecular Weight | 449.59 |
| CAS Numbers | 1219925-73-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | E6446; E 6446; E-6446 |
| IUPAC/Chemical Name | 6-(3-Pyrrolidin-1-yl-propoxy)-2-[4-(3-pyrrolidin-1-yl-propoxy)-phenyl]-benzooxazole |
| InChl Key | YMYJXFUPMPMETB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C27H35N3O3/c1-2-14-29(13-1)17-5-19-31-23-9-7-22(8-10-23)27-28-25-12-11-24(21-26(25)33-27)32-20-6-18-30-15-3-4-16-30/h7-12,21H,1-6,13-20H2 |
| SMILES Code | C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1 |
| References | 1) Dias AA, Silva CO, Santos JP, Batista-Silva LR, Acosta CC, Fontes AN, Pinheiro RO, Lara FA, Machado AM, Nery JA, Sarno EN, Pereira GM, Pessolani MC. DNA Sensing via TLR-9 Constitutes a Major Innate Immunity Pathway Activated during Erythema Nodosum Leprosum. J Immunol. 2016 Sep 1;197(5):1905-13. 2) Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40. |
More info
Novel antagonist of nucleic acid-sensing TLRs, potently suppressing DNA stimulation of HEK:TLR9 cells
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