EAA Receptors

 ORG-26576 View larger

ORG-26576

AOB37914

CAS: 1026791-61-6

 

Chemical Name: (3S)-3,4-Propano-2,3-dihydropyrido[3,2-f][1,4]oxazepine-5(4H)-one

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$25.00

$25.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.25 Total: $1,125.00
150 $13.00 Total: $650.00
125 $15.25 Total: $381.25
110 $18.00 Total: $180.00
15 $21.25 Total: $106.25

Data sheet

Molecular FormulaC11H12N2O2
Molecular Weight 204.23
CAS Numbers1026791-61-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
SynonymOrg-26576; Org26576; Org 26576
IUPAC/Chemical Name(3S)-3,4-Propano-2,3-dihydropyrido[3,2-f][1,4]oxazepine-5(4H)-one
InChl KeyFIKUEZUFASUKAH-QMMMGPOBSA-N
InChl CodeInChI=1S/C11H12N2O2/c14-11-9-4-1-5-12-10(9)15-7-8-3-2-6-13(8)11/h1,4-5,8H,2-3,6-7H2/t8-/m0/s1
SMILES CodeO=C1N(CCC2)[C@]2([H])COC3=NC=CC=C13
References1) Nations KR, et al L. Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial. J Psychopharmacol. 2012 Dec;26(12):1525-39. doi: 10.1177/0269881112458728. PubMed PMID: 22954616.

2) Nations KR, et al., Maximum tolerated dose evaluation of the AMPA modulator Org 26576 in healthy volunteers and depressed patients: a summary and method analysis of bridging research in support of phase II dose selection. Drugs R D. 2012 Sep 1;12(3):127-39. doi: 10.2165/11634360-000000000-00000. PubMed PMID: 22852579; PubMed Central PMCID: PMC3585695.

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Novel AMPA receptor positive allosteric modulator