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TASIN-1 Hydrochloride
AOB31799
CAS No: 1678515-13-3 (free base: 792927-06-1)
Chemical Name: Truncated APC Selective INhibitor-1; 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine hydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C18H29ClN2O3S |
| Molecular Weight | 388.95 |
| CAS Numbers | 1678515-13-3 (free base: 792927-06-1) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | TASIN-1 Hydrochloride; TASIN 1 Hydrochloride; TASIN1 Hydrochloride; TASIN-1 HCl; TASIN 1 HCl; TASIN1 HCl; Truncated APC Selective INhibitor-1; |
| IUPAC/Chemical Name | 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine hydrochloride |
| InChl Key | TXDTUQPRRXNCLP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)16-9-13-20(14-10-16)24(21,22)18-5-3-17(23-2)4-6-18;/h3-6,15-16H,7-14H2,1-2H3;1H |
| SMILES Code | CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.[H]Cl |
| References | 1) Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Mol Cancer Ther. 2018 Feb 21. pii: molcanther.0887.2017. 2) Cully M. Anticancer drugs: Exploiting a weakness in colorectal cancers. Nat Rev Drug Discov. 2016 Nov 29;15(12):820-821. |
More info
Novel truncated APC selective inhibitor, selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signalling in colon cancer cells
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