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Trodusquemine (MSI-1436)
AOB33327
CAS: 186139-09-3
Chemical Name: MSI-1436; Aminosterol-1436
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $225.00 | Total: $22,500.00 |
| 1 | 50 | $260.00 | Total: $13,000.00 |
| 1 | 25 | $305.00 | Total: $7,625.00 |
| 1 | 10 | $360.00 | Total: $3,600.00 |
| 1 | 5 | $425.00 | Total: $2,125.00 |
Data sheet
| Molecular Formula | C37H72N4O5S |
| Molecular Weight | 685.07 |
| CAS Numbers | 186139-09-3 (free base) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Trodusquemine; MSI-1436; MSI1436; MSI 1436; MSI-1436C; MSI1436C; MSI 1436C; Aminosterol 1436; Aminosterol1436; Aminosterol-1436 |
| IUPAC/Chemical Name | (3R,6R)-6-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-7-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptan-3-yl hydrogen sulfate |
| InChl Key | WUJVPODXELZABP-FWJXURDUSA-N |
| InChl Code | InChI=1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1 |
| SMILES Code | CC([C@H](OS(=O)(O)=O)CC[C@H]([C@H]1CC[C@H]2[C@@H]3[C@@H](C[C@H]4C[C@@H] |
| References | 1) Lantz KA, Hart SG, Planey SL, Roitman MF, Ruiz-White IA, Wolfe HR, McLane MP. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23. 2) Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7. doi: 10.1016/j.bbrc.2015.01.040. PubMed PMID: 25623533.3) Salmi C, Loncle C, Vidal N, Laget M, Letourneux Y, Brunel JM. Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine. J Enzyme Inhib Med Chem. 2008 Dec;23(6):860-5. |
More info
Naturally-occurring cholestane and non-competitive, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B), with potential hypoglycemic, anti-diabetic, anti-obesity, and antineoplastic activities
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