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> Pathway Inhibitors>Enzyme Inhibitors>Trodusquemine (MSI-1436)

Enzyme Inhibitors

Trodusquemine (MSI-1436) View larger

Trodusquemine (MSI-1436)

AOB33327

CAS: 186139-09-3

Chemical Name: MSI-1436; Aminosterol-1436

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$500.00

$500.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $425.00 Total: $2,125.00
110 $360.00 Total: $3,600.00
125 $305.00 Total: $7,625.00
150 $260.00 Total: $13,000.00
1100 $225.00 Total: $22,500.00

Data sheet

Molecular FormulaC37H72N4O5S
Molecular Weight685.07
CAS Numbers186139-09-3 (free base)
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymTrodusquemine; MSI-1436; MSI1436; MSI 1436; MSI-1436C; MSI1436C; MSI 1436C; Aminosterol 1436; Aminosterol1436; Aminosterol-1436
IUPAC/Chemical Name(3R,6R)-6-((3S,5R,7R,8R,9S,10S,13R,14S,17R)-3-((3-((4-((3-aminopropyl)amino)butyl)amino)propyl)amino)-7-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptan-3-yl hydrogen sulfate
InChl KeyWUJVPODXELZABP-FWJXURDUSA-N
InChl Code InChI=1S/C37H72N4O5S/c1-26(2)34(46-47(43,44)45)13-10-27(3)30-11-12-31-35-32(15-17-37(30,31)5)36(4)16-14-29(24-28(36)25-33(35)42)41-23-9-22-40-20-7-6-19-39-21-8-18-38/h26-35,39-42H,6-25,38H2,1-5H3(H,43,44,45)/t27-,28-,29+,30-,31+,32+,33-,34-,35+,36+,37-/m1/s1
SMILES CodeCC([C@H](OS(=O)(O)=O)CC[C@H]([C@H]1CC[C@H]2[C@@H]3[C@@H](C[C@H]4C[C@@H]
References1) Lantz KA, Hart SG, Planey SL, Roitman MF, Ruiz-White IA, Wolfe HR, McLane MP. Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. Obesity (Silver Spring). 2010 Aug;18(8):1516-23.

2) Qin Z, et al. Functional properties of Claramine: a novel PTP1B inhibitor and insulin-mimetic compound. Biochem Biophys Res Commun. 2015 Feb 27;458(1):21-7. doi: 10.1016/j.bbrc.2015.01.040. PubMed PMID: 25623533.3) Salmi C, Loncle C, Vidal N, Laget M, Letourneux Y, Brunel JM. Antimicrobial activities of 3-amino- and polyaminosterol analogues of squalamine and trodusquemine. J Enzyme Inhib Med Chem. 2008 Dec;23(6):860-5.

More info

Naturally-occurring cholestane and non-competitive, allosteric inhibitor of protein tyrosine phosphatase 1B (PTP1B), with potential hypoglycemic, anti-diabetic, anti-obesity, and antineoplastic activities







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