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> Pathway Inhibitors>Enzyme Inhibitors>ARN-21934

Enzyme Inhibitors

ARN-21934 View larger

ARN-21934

AOB14707

CAS: 2230854-93-8

 

Chemical Name: N4-(4-(Dimethylamino)phenyl)-2-(pyridin-4-yl)-5,6,7,8-tetrahydroquinazoline-4,6-diamine

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$37.00

$37.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $31.45 Total: $157.25
110 $26.64 Total: $266.40
125 $22.57 Total: $564.25
150 $19.24 Total: $962.00
1100 $16.65 Total: $1,665.00

Data sheet

Molecular FormulaC21H24N6
Molecular Weight360.47
CAS Numbers2230854-93-8
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymARN-21934; ARN21934; ARN 21934;
IUPAC/Chemical NameN4-(4-(dimethylamino)phenyl)-2-(pyridin-4-yl)-5,6,7,8-tetrahydroquinazoline-4,6-diamine
InChl KeyCKXSRLUXTFDZCF-UHFFFAOYSA-N
InChl CodeInChI=1S/C21H24N6/c1-27(2)17-6-4-16(5-7-17)24-21-18-13-15(22)3-8-19(18)25-20(26-21)14-9-11-23-12-10-14/h4-7,9-12,15H,3,8,13,22H2,1-2H3,(H,24,25,26)
SMILES CodeNC1CC2=C(NC3=CC=C(N(C)C)C=C3)N=C(C4=CC=NC=C4)N=C2CC1
References1) Ortega JA, Arencibia JM, Minniti E, Byl JAW, Franco-Ulloa S, Borgogno M, Genna V, Summa M, Bertozzi SM, Bertorelli R, Armirotti A, Minarini A, Sissi C, Osheroff N, De Vivo M. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020 Oct 20. doi: 10.1021/acs.jmedchem.0c00774. Epub ahead of print. PMID: 33079544.

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Novel potent and highly selective inhibitor for human topoisomerase II α over β