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Enzyme Inhibitors

MKC442 View larger

MKC442

AOB2926

CAS: 149950-60-7

 

Chemical Name: Emivirine; I-EBU; MKC-442; 6-Benzyl-1-(ethoxymethyl)-5-isopropylpyrimidine-2,4(1H,3H)-dione

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$37.00

$37.00 per 1 mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
5 $31.45 Total: $157.25
10 $26.64 Total: $266.40
25 $22.57 Total: $564.25
50 $19.24 Total: $962.00
100 $16.65 Total: $1,665.00

Data sheet

Molecular FormulaC17H22N2O3
Molecular Weight302.37
CAS Numbers149950-60-7
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO and Alcohol
Purity98% by HPLC
SynonymMKC-442; MKC442; MKC 442; DRG-0302; DRG0302; DRG 0302; I-EBU; Emivirine.
IUPAC/Chemical Name1-(Ethoxymethyl)-5-(1-methylethyl)-6-(phenylmethyl)-2,4(1H,3H)-pyrimidinedione
InChl KeyMLILORUFDVLTSP-UHFFFAOYSA-N
InChl CodeInChI=1S/C17H22N2O3/c1-4-22-11-19-14(10-13-8-6-5-7-9-13)15(12(2)3)16(20)18-17(19)21/h5-9,12H,4,10-11H2,1-3H3,(H,18,20,21)
SMILES CodeO=C1NC(C(C(C)C)=C(CC2=CC=CC=C2)N1COCC)=O
References1) El-Brollosy NR, Loddo R. Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651. Drug Res (Stuttg). 2016 Apr;66(4):181-8. doi: 10.1055/s-0035-1559683. Epub 2015 Aug 27. PubMed PMID: 26313923.

2) El-Brollosy NR, Sørensen ER, Pedersen EB, Sanna G, La Colla P, Loddo R. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008 Jan;341(1):9-19. PubMed PMID: 18161905.

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Highly selective non-nucleoside reverse transcriptase inhibitor of HIV-1