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OSMI-1
AOB5700
CAS No: 1681056-61-0
Chemical Name: (R)-N-(Furan-2-ylmethyl)-2-(2-methoxyphenyl)-2-(2-oxo-1,2-dihydroquinoline-6-sulfonamido)-N-(thiophen-2-ylmethyl)acetamide
AOBIOUS launched this product in 2015
CITATIONS - Publications That Use AOBIOUS Product
1) O-GlcNAcylation enhances the tumorigenic properties of cervical cancer cells in vitro
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $12.98 | Total: $1,298.25 |
| 1 | 50 | $15.00 | Total: $750.10 |
| 1 | 25 | $17.60 | Total: $439.96 |
| 1 | 10 | $20.77 | Total: $207.72 |
| 1 | 5 | $24.52 | Total: $122.61 |
Data sheet
| Molecular Formula | C28H25N3O6S2 |
| Molecular Weight | 563.64 |
| CAS Numbers | 1681056-61-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | OSMI-1; OSMI 1; OSMI1 |
| IUPAC/Chemical Name | αR-[[(1,2-dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide |
| InChl Key | IYIGLWQQAMROOF-HHHXNRCGSA-N |
| InChl Code | InChI=1S/C28H25N3O6S2/c1-36-25-9-3-2-8-23(25)27(28(33)31(17-20-6-4-14-37-20)18-21-7-5-15-38-21)30-39(34,35)22-11-12-24-19(16-22)10-13-26(32)29-24/h2-16,27,30H,17-18H2,1H3,(H,29,32)/t27-/m1/s1 |
| SMILES Code | O=C([C@@H](C1=CC=CC=C1OC)NS(C2=CC(C=CC(N3)=O)=C3C=C2)(=O)=O)N(CC4=CC=CO4)CC5=CC=CS5 |
| References | 1) Park SK, et al. A Conserved Splicing Silencer Dynamically Regulates O-GlcNAc Transferase Intron Retention and O-GlcNAc Homeostasis. Cell Rep. 2017 Aug 1;20(5):1088-1099. 2) Angelova M, et al. Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus. J Virol. 2015 Aug;89(16):8474-83. 3) Ortiz-Meoz, R.F., Jiang, J., Lazarus, M.B., et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol. 10(6), 1392-1397 (2015). |
More info
Novel inhibitor of O-GlcNAc transferase (OGT)
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