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View larger 
GSK620 Bulk
AOB11616B
CAS: 2088410-46-0
Chemical Name: 1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | 25 mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $56.25 | Total: $5,625.00 |
| 1 | 50 | $65.00 | Total: $3,250.00 |
| 1 | 25 | $76.25 | Total: $1,906.25 |
| 1 | 10 | $90.00 | Total: $900.00 |
| 1 | 5 | $106.25 | Total: $531.25 |
Data sheet
| Molecular Formula | C18H19N3O3 |
| Molecular Weight | 325.37 |
| CAS Numbers | 2088410-46-0 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO: Sparingly Soluble: 1-10 mg/ml |
| Purity | 98% by HPLC |
| Synonym | GSK-620; GSK 620 |
| IUPAC/Chemical Name | 1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide |
| InChl Key | QZZCUOVXHPAQRQ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H19N3O3/c1-19-17(23)15-9-13(16(22)20-14-7-8-14)11-21(18(15)24)10-12-5-3-2-4-6-12/h2-6,9,11,14H,7-8,10H2,1H3,(H,19,23)(H,20,22) |
| SMILES Code | O=C(C(C=C1C(NC)=O)=CN(CC2=CC=CC=C2)C1=O)NC3CC3 |
| References | 1) Gilan, O., et al., Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation, Science 24 Apr 2020: Vol. 368, Issue 6489, pp. 387-394 DOI: 10.1126/science.aaz8455 2)Seal, J.T., Atkinson, S.J., Aylott, H., et al. The optimization of a novel, weak bromo and extra terminal domain (BET) bromodomain fragment ligand to a potent and selective second bromodomain (BD2) inhibitor. J. Med. Chem. 63(17), 9093-9126 (2020). |
More info
Novel BD2-selective BET inhibitor in vivo tool , binding to the individual tandem bromodomains [BD1 and BD2] of BRD2, BRD3, BRD4, and BRDT