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> Pathway Inhibitors>Enzyme Inhibitors>GSK620 Bulk

Enzyme Inhibitors

GSK620 View larger

GSK620 Bulk

AOB11616B

CAS: 2088410-46-0

 

Chemical Name: 1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide

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$125.00

$125.00 per 25 mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity25 mgUnit Price ($/mg or $/Unit)Final Price
15 $106.25 Total: $531.25
110 $90.00 Total: $900.00
125 $76.25 Total: $1,906.25
150 $65.00 Total: $3,250.00
1100 $56.25 Total: $5,625.00

Data sheet

Molecular FormulaC18H19N3O3
Molecular Weight325.37
CAS Numbers2088410-46-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO: Sparingly Soluble: 1-10 mg/ml
Purity98% by HPLC
SynonymGSK-620; GSK 620
IUPAC/Chemical Name1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide
InChl KeyQZZCUOVXHPAQRQ-UHFFFAOYSA-N
InChl CodeInChI=1S/C18H19N3O3/c1-19-17(23)15-9-13(16(22)20-14-7-8-14)11-21(18(15)24)10-12-5-3-2-4-6-12/h2-6,9,11,14H,7-8,10H2,1H3,(H,19,23)(H,20,22)
SMILES CodeO=C(C(C=C1C(NC)=O)=CN(CC2=CC=CC=C2)C1=O)NC3CC3
References1) Gilan, O., et al., Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation, Science 24 Apr 2020: Vol. 368, Issue 6489, pp. 387-394 DOI: 10.1126/science.aaz8455

2)Seal, J.T., Atkinson, S.J., Aylott, H., et al. The optimization of a novel, weak bromo and extra terminal domain (BET) bromodomain fragment ligand to a potent and selective second bromodomain (BD2) inhibitor. J. Med. Chem. 63(17), 9093-9126 (2020).

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Novel BD2-selective BET inhibitor in vivo tool , binding to the individual tandem bromodomains [BD1 and BD2] of BRD2, BRD3, BRD4, and BRDT