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NU9056 DMSO
AOB2773
CAS No: 1450644-28-6
Chemical Name: 1,2-Bis(isothiazol-5-yl)disulfane
Supply in DMSO at concentration of 10 mg/mL
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Data sheet
| Molecular Formula | C6H4N2S4 |
| Molecular Weight | 232.37 |
| CAS Numbers | 1450644-28-6 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | NU-9056; NU 9056; NU9056 |
| IUPAC/Chemical Name | 5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole |
| InChl Key | MLRAMCAHIWHWRM-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H |
| SMILES Code | C1(SSC2=CC=NS2)=CC=NS1 |
| References | 1) Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207 |
More info
Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation
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