Epigenetics

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NU9056 DMSO

AOB2773

CAS No: 1450644-28-6

 

Chemical Name: 1,2-Bis(isothiazol-5-yl)disulfane

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Supply in DMSO at concentration of 10 mg/mL

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$79.00

$79.00 per 5 mg

Data sheet

Molecular FormulaC6H4N2S4
Molecular Weight232.37
CAS Numbers1450644-28-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymNU-9056; NU 9056; NU9056
IUPAC/Chemical Name5-(1,2-Thiazol-5-yldisulfanyl)-1,2-thiazole
InChl KeyMLRAMCAHIWHWRM-UHFFFAOYSA-N
InChl CodeInChI=1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H
SMILES CodeC1(SSC2=CC=NS2)=CC=NS1
References1) Coffey et al (2012) Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One 7 e45539 PMID: 23056207

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Selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Decreases proliferation of LNCaP cells; induces apoptosis via caspase activation

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