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GNE-781
AOB33320
CAS: 1936422-33-1
Chemical Name: 3-(7-(Difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide
1938 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $42.07 | Total: $210.37 |
| 1 | 10 | $35.64 | Total: $356.40 |
| 1 | 25 | $30.20 | Total: $754.88 |
| 1 | 50 | $25.74 | Total: $1,287.00 |
| 1 | 100 | $22.28 | Total: $2,227.50 |
Overview
Novel Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP)
Chemical Properties
| Molecular Formula | C27H33F2N7O2 |
| Molecular Weight | 525.61 |
| CAS Numbers | 1936422-33-1 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-N-methyl-1-tetrahydropyran-4-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide |
| InChl Key | CQCWHSDMJBAGDC-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C27H33F2N7O2/c1-30-27(37)34-9-5-23-22(16-34)26(32-36(23)19-6-10-38-11-7-19)35-8-3-4-17-12-20(18-14-31-33(2)15-18)21(25(28)29)13-24(17)35/h12-15,19,25H,3-11,16H2,1-2H3,(H,30,37) |
| SMILES Code | O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
GNE-781; GNE 781; GNE781.
References
1) Romero FA, et al GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP). J Med Chem. 2017 Sep 11
