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AOB17561
CAS: 849658-87-3
Chemical Name: (1s,2r,3s,4r)-3-((4-(4-Isopropylphenyl)-5-methylthiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid
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Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
---|---|---|---|
1 | 100 | $35.55 | Total: $3,555.00 |
1 | 50 | $41.08 | Total: $2,054.00 |
1 | 25 | $48.19 | Total: $1,204.75 |
1 | 10 | $56.88 | Total: $568.80 |
1 | 5 | $67.15 | Total: $335.75 |
Molecular Formula | C22H26N2O3S |
Molecular Weight | 398.521 |
CAS Numbers | 849658-87-3 |
Storage Condition | 0°C (short term), -20°C (long term), desiccated |
Solubility | DMSO |
Purity | 98% by HPLC |
Synonym | PKZ18; PKZ 18; PKZ-18 |
IUPAC/Chemical Name | (1s,2r,3s,4r)-3-((4-(4-Isopropylphenyl)-5-methylthiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid |
InChl Key | HWHYSSATNZEECJ-VSZNYVQBSA-N |
InChl Code | InChI=1S/C22H26N2O3S/c1-11(2)13-4-6-14(7-5-13)19-12(3)28-22(23-19)24-20(25)17-15-8-9-16(10-15)18(17)21(26)27/h4-7,11,15-18H,8-10H2,1-3H3,(H,26,27)(H,23,24,25)/t15-,16+,17+,18-/m1/s1 |
SMILES Code | O=C([C@@H]1[C@@](C2)([H])CC[C@@]2([H])[C@@H]1C(NC3=NC(C4=CC=C(C(C)C)C=C4)=C(C)S3)=O)O |
References | 1) Frohlich KM, Weintraub SF, Bell JT, Todd GC, Väre VYP, Schneider R, Kloos ZA, Tabe ES, Cantara WA, Stark CJ, Onwuanaibe UJ, Duffy BC, Basanta-Sanchez M, Kitchen DB, McDonough KA, Agris PF. Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria. ChemMedChem. 2019 Apr 3;14(7):758-769. doi: 10.1002/cmdc.201800744. Epub 2019 Mar 1. PubMed PMID: 30707489. |
Novel antibiotic against a unique tRNA-mediated regulation of transcription in Gram-positive bacteria, significantly inhibiting in vivo transcription of glycyl-tRNA synthetase mRNA, also inhibiting in vivo translation of the S. aureus threonyl-tRNA synthetase protein