Function Modulators

Gingerenone A View larger

Gingerenone A

AOB6505

CAS: 128700-97-0

 

Chemical Name: AS-HK014; (4E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one

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Data sheet

Molecular FormulaC21H24N5
Molecular Weight356.41
CAS Numbers128700-97-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymAS-HK014; AS HK014; ASHK014; Gingerenone A; Gingerenone-A;
IUPAC/Chemical Name (4E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-4-hepten-3-one
InChl KeyFWDXZNKYDTXGOT-GQCTYLIASA-N
InChl CodeInChI=1S/C21H24O5/c1-25-20-13-15(8-11-18(20)23)5-3-4-6-17(22)10-7-16-9-12-19(24)21(14-16)26-2/h4,6,8-9,11-14,23-24H,3,5,7,10H2,1-2H3/b6-4+
SMILES CodeO=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
References1) Alkhaldi AA, Creek DJ, Ibrahim H, Kim DH, Quashie NB, Burgess KE, Changtam C, Barrett MP, Suksamrarn A, de Koning HP. Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on trypanosoma brucei by forming an adduct with trypanothione. Mol Pharmacol. 2015;87(3):451-64. doi: 10.1124/mol.114.096016. Epub 2014 Dec 19. PubMed PMID: 25527638.

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Potent trypanocidal curcumin analog bearing a mono-enone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione