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> Function Modulators>VISTA modulator 6809-0223

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VISTA modulator 6809-0223 View larger

VISTA modulator 6809-0223

AOB14462

CAS: 669749-25-1

 

Chemical Name: 2-((4,6-Dimethylquinazolin-2-yl)amino)-6-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)pyrimidin-4(3H)-one

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$129.00

$129.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $109.65 Total: $548.25
110 $92.88 Total: $928.80
125 $78.69 Total: $1,967.25
150 $67.08 Total: $3,354.00
1100 $58.05 Total: $5,805.00

Data sheet

Molecular FormulaC18H17N7OS2
Molecular Weight411.50
CAS Numbers669749-25-1
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymVISTA modulator 6809-0223; VISTA modulator 68090223; VISTA modulator 6809 0223;
IUPAC/Chemical Name2-((4,6-dimethylquinazolin-2-yl)amino)-6-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)pyrimidin-4(3H)-one
InChl KeyYIJOQQHVEVIMNS-UHFFFAOYSA-N
InChl CodeInChI=1S/C18H17N7OS2/c1-9-4-5-14-13(6-9)10(2)19-16(21-14)23-17-20-12(7-15(26)22-17)8-27-18-25-24-11(3)28-18/h4-7H,8H2,1-3H3,(H2,19,20,21,22,23,26)
SMILES CodeO=C1NC(NC2=NC(C)=C3C=C(C)C=CC3=N2)=NC(CSC4=NN=C(C)S4)=C1
References1) Zong L, Yu S, Mo S, Zhou Y, Xiang Y, Lu Z, Chen J. High VISTA Expression Correlates With a Favorable Prognosis in Patients With Colorectal Cancer. J Immunother. 2021 Jan;44(1):22-28.

More info

Novel immune checkpoint VISTA (V-domain immunoglobulin suppressor of T-cell activation) modulator

The VISTA modulator 6809-0223 is a small-molecule chemical modulator that targets the VISTA immune checkpoint protein (V-domain Immunoglobulin Suppressor of T-cell Activation) — a novel immune regulatory receptor involved in suppressing T-cell activity. Aobious+1

What it actually does

1. Modulates the VISTA immune checkpoint

  • VISTA is an immune checkpoint protein expressed on various immune cells that dampens T-cell responses to help maintain immune homeostasis and prevent excessive inflammation. PubMed

  • Compound 6809-0223 acts as a small-molecule modulator of VISTA — meaning it binds to the VISTA protein and interferes with its immune-suppressive signaling. PubMed

2. It functions primarily as an antagonist (inhibitor) of VISTA

  • In research models, 6809-0223 binds to VISTA’s extracellular domain with measurable affinity and blocks its immune-inhibitory effects on T cells. PubMed Central

  • By reducing VISTA’s inhibitory signaling, the compound can increase T-cell activity, including:

    • Enhanced cytokine production (e.g., IL-2, IFN-γ). PubMed Central

    • Increased CD4⁺ T-cell proliferation in the presence of VISTA. PubMed Central

Mechanism of action (in research models)

  • Binding: 6809-0223 interacts with specific residues on the extracellular domain of murine or human VISTA, as confirmed by docking and binding studies. PubMed Central

  • Functional effect: When VISTA normally suppresses T-cell activation, adding 6809-0223 can counteract that suppression, resulting in more active T cells and increased immune signaling. PubMed Central

Context of use

This compound is used primarily in preclinical research to study VISTA biology and to evaluate potential immune-modulating effects, especially for cancer immunotherapy research, where blocking immune checkpoints like VISTA may enhance anti-tumor immunity. PubMed