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View larger CHMFL-EGFR-202
AT10802
CAS 2089381-40-6
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $84.15 | Total: $420.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 100 | $44.55 | Total: $4,455.00 |
Data sheet
| Molecular Formula | C25H24ClN7O2 |
| Molecular Weight | 489.96 |
| CAS Numbers | 2089381-40-6 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | NC1=C2C(=NN(C2=NC=N1)[C@H]3CN(C(C=C)=O)CCC3)C4=CC(Cl)=C(OCC5=CC=CC=N5)C=C4 |
| References | Wang A, et al. Discovery of [R]-1-[3-[4-Amino-3-[3-chloro-4-[pyridin-2-ylmethoxy]phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one [CHMFL-EGFR-202] as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode. |
More info
CHMFL-EGFR-202 is a potent, irreversible inhibitor of EGFR mutant kinase with IC50 values of 5.3 nM for drug-resistant mutant EGFR T790M and 8.3 nM for WT EGFR kinases.