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View larger PF-06459988
AT16492
CAS 1428774-45-1
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $107.95 | Total: $539.75 |
| 1 | 10 | $91.44 | Total: $914.40 |
| 1 | 25 | $77.47 | Total: $1,936.75 |
| 1 | 50 | $66.04 | Total: $3,302.00 |
| 1 | 100 | $57.15 | Total: $5,715.00 |
Data sheet
| Molecular Formula | C19H22ClN7O3 |
| Molecular Weight | 431.88 |
| CAS Numbers | 1428774-45-1 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | CO[C@H]1CN(C[C@@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C |
| References | Cheng H, et al. Discovery of 1-{[3R,4R]-3-[[{5-Chloro-2-[[1-methyl-1H-pyrazol-4-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy]methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one [PF-06459988], a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59[5] 2005-24. doi 10.1021acs.jmedchem.5b01633. Epub 2016 Jan 28. |
More info
PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.