Growth Factors Receptors

PF-06459988 View larger

PF-06459988

AT16492

CAS 1428774-45-1

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$127.00

$127.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $57.15 Total: $5,715.00
150 $66.04 Total: $3,302.00
125 $77.47 Total: $1,936.75
110 $91.44 Total: $914.40
15 $107.95 Total: $539.75

Data sheet

Molecular FormulaC19H22ClN7O3
Molecular Weight431.88
CAS Numbers1428774-45-1
Storage Condition0C Short Term, -20C Long Term
SolubilityDMSO
Purity98% by HPLC
SMILES CodeCO[C@H]1CN(C[C@@H]1COc1nc(Nc2cnn(C)c2)nc2[nH]cc(Cl)c12)C(=O)C=C
ReferencesCheng H, et al. Discovery of 1-{[3R,4R]-3-[[{5-Chloro-2-[[1-methyl-1H-pyrazol-4-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy]methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one [PF-06459988], a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. J Med Chem. 2016 Mar 10;59[5] 2005-24. doi 10.1021acs.jmedchem.5b01633. Epub 2016 Jan 28.

More info

PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.