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FG-4592 (Roxadustat)
AOB87739
CAS No:808118-40-3
Chemical Name: (4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $2.25 | Total: $225.00 |
| 1 | 50 | $2.60 | Total: $130.00 |
| 1 | 25 | $3.05 | Total: $76.25 |
| 1 | 10 | $3.60 | Total: $36.00 |
| 1 | 5 | $4.25 | Total: $21.25 |
Data sheet
| Molecular Formula | C19H16N2O5 |
| Molecular Weight | 352.34 |
| CAS Numbers | 808118-40-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Stock Solution Guide | 10 mMol/3.52 mg/1 mL of DMSO |
| Purity | 98% by HPLC |
| Synonym | ASP1517; ASP 1517; ASP-1517; FG-4592; FG 4592; FG4592; Roxadustat. |
| IUPAC/Chemical Name | (4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine |
| InChl Key | YOZBGTLTNGAVFU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23) |
| SMILES Code | O=C(O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC3=CC=CC=C3)C=C2)=O |
| References | 1) Besarab A, Provenzano R, Hertel J, Zabaneh R, Klaus SJ, Lee T, Leong R, Hemmerich S, Yu KH, Neff TB. Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients. Nephrol Dial Transplant. 2015 Oct;30(10):1665-73.2) Forristal CE, Levesque JP. Targeting the hypoxia-sensing pathway in clinical hematology. Stem Cells Transl Med. 2014 Feb;3(2):135-40. 3) Cases A. The latest advances in kidney diseases and related disorders. Drug News Perspect. 2007 Dec;20(10):647-54. |
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an inhibitor of hypoxia inducible factor (HIF) prolyl hydroxylase
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