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> Pathway Inhibitors>Enzyme Inhibitors>Hydroxylases>FG-4592 (Roxadustat)

Hydroxylases

FG-4592 (Roxadustat) View larger

FG-4592 (Roxadustat)

AOB87739

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $8.50 Total: $42.50
110 $7.20 Total: $72.00
125 $6.10 Total: $152.50
150 $5.20 Total: $260.00
1100 $4.50 Total: $450.00

Data sheet

Molecular FormulaC19H16N2O5
Molecular Weight352.34
CAS Numbers808118-40-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Stock Solution Guide10 mMol/3.52 mg/1 mL of DMSO
Purity98% by HPLC
SynonymASP1517; ASP 1517; ASP-1517; FG-4592; FG 4592; FG4592; Roxadustat.
IUPAC/Chemical Name(4-hydroxy-1-methyl-7-phenoxyisoquinoline-3-carbonyl)glycine
InChl KeyYOZBGTLTNGAVFU-UHFFFAOYSA-N
InChl CodeInChI=1S/C19H16N2O5/c1-11-15-9-13(26-12-5-3-2-4-6-12)7-8-14(15)18(24)17(21-11)19(25)20-10-16(22)23/h2-9,24H,10H2,1H3,(H,20,25)(H,22,23)
SMILES CodeO=C(O)CNC(C1=C(O)C2=C(C(C)=N1)C=C(OC3=CC=CC=C3)C=C2)=O
References1) Besarab A, Provenzano R, Hertel J, Zabaneh R, Klaus SJ, Lee T, Leong R, Hemmerich S, Yu KH, Neff TB. Randomized placebo-controlled dose-ranging and pharmacodynamics study of roxadustat (FG-4592) to treat anemia in nondialysis-dependent chronic kidney disease (NDD-CKD) patients. Nephrol Dial Transplant. 2015 Oct;30(10):1665-73.2) Forristal CE, Levesque JP. Targeting the hypoxia-sensing pathway in clinical hematology. Stem Cells Transl Med. 2014 Feb;3(2):135-40.

3) Cases A. The latest advances in kidney diseases and related disorders. Drug News Perspect. 2007 Dec;20(10):647-54.

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