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OTSSP167 Hydrochloride
AOB37599
CAS: 1431698-10-0
Chemical Name: 1-(6-(3,5-Dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethan-1-one, monohydrochloride
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $6.75 | Total: $675.00 |
| 1 | 50 | $7.80 | Total: $390.00 |
| 1 | 25 | $9.15 | Total: $228.75 |
| 1 | 10 | $10.80 | Total: $108.00 |
| 1 | 5 | $12.75 | Total: $63.75 |
Data sheet
| Molecular Formula | C25H29Cl3N4O2 |
| Molecular Weight | 523.88 |
| CAS Numbers | 1431698-10-0 (HCl) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO and Alcohol |
| Purity | 98% by HPLC |
| Synonym | OTSSP167; OTSSP-167; OTSSP 167; OTS167; OTS-167; OTS 167; OTSSP167 HCl; OTS167 HCl; OTSSP167 hydrochloride |
| IUPAC/Chemical Name | 1-(6-(3,5-dichloro-4-hydroxyphenyl)-4-(((1r,4r)-4-((dimethylamino)methyl)cyclohexyl)amino)-1,5-naphthyridin-3-yl)ethanone hydrochloride |
| InChl Key | XDGWHISAOWEFML-BFLZMHAMSA-N |
| InChl Code | InChI=1S/C25H28Cl2N4O2.ClH/c1-14(32)18-12-28-22-9-8-21(16-10-19(26)25(33)20(27)11-16)30-24(22)23(18)29-17-6-4-15(5-7-17)13-31(2)3;/h8-12,15,17,33H,4-7,13H2,1-3H3,(H,28,29);1H/t15-,17-; |
| SMILES Code | CC(C1=C(N[C@H]2CC[C@H](CN(C)C)CC2)C3=NC(C4=CC(Cl)=C(O)C(Cl)=C4)=CC=C3N=C1)=O.[H]Cl |
| References | 1) Wang J, Wang Y, Shen F, Xu Y, Zhang Y, Zou X, Zhou J, Chen Y. Maternal embryonic leucine zipper kinase: A novel biomarker and a potential therapeutic target of cervical cancer. Cancer Med. 2018 Nov;7(11):5665-5678. doi: 10.1002/cam4.1816. Epub 2018 Oct 18. PubMed PMID: 30334367; PubMed Central PMCID: PMC6246930. 2) Meel MH, et al. MELK Inhibition in Diffuse Intrinsic Pontine Glioma. Clin Cancer Res. 2018 Nov 15;24(22):5645-5657. doi: 10.1158/1078-0432.CCR-18-0924. Epub 2018 Jul 30. PubMed PMID: 30061363. |
More info
Potent inhibitor of MELK, suppressing the growth of diverse cancer cell lines