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PF-06826647
AOB11026
CAS: 2127109-84-4
Chemical Name: (1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile
AOBIOUS launched this product in 2021
CITATIONS - Publications That Use AOBIOUS Product
342 Items
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $80.75 | Total: $403.75 |
| 1 | 10 | $68.40 | Total: $684.00 |
| 1 | 25 | $57.95 | Total: $1,448.75 |
| 1 | 50 | $49.40 | Total: $2,470.00 |
| 1 | 100 | $42.75 | Total: $4,275.00 |
Overview
Novel Selective Tyrosine Kinase 2 (TYK2) Inhibitor for the Treatment of Autoimmune Diseases
Chemical Properties
| Molecular Formula | C20H17N9 |
| Molecular Weight | 383.42 |
| CAS Numbers | 2127109-84-4 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | (1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile |
| InChl Key | XPLZTJWZDBFWDE-OYOVHJISSA-N |
| InChl Code | InChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3/t14-,20- |
| SMILES Code | N#C[C@@H]1C[C@@](CC#N)(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5N=CC=C35)=C2)C1 |
Storage and Handling
0°C (short term), -20°C (long term), desiccated
Synonyms
PF-06826647; PF 06826647; PF06826647; PF-6826647; PF 6826647; PF6826647; Tyk2-IN-8; Tyk2-IN 8; Tyk2-IN8;
References
1) Brian S., et al., Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases, J. Med. Chem. 2020, 63, 22, 13561–13577
2) Miguel Nogueira, et al., JAK Inhibitors for Treatment of Psoriasis: Focus on Selective TYK2 Inhibitors, Drugs 2020 Mar;80(4):341-352
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