Kinase Inhibitors

PF-06826647 View larger

PF-06826647

AOB11026

CAS: 2127109-84-4

 

Chemical Name: (1r,3r)-3-(Cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile

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$95.00

$95.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

Quantity (mg or Unit)Unit Price ($/mg or $/Unit)Final Price
100 $42.75 Total: $4,275.00
50 $49.40 Total: $2,470.00
25 $57.95 Total: $1,448.75
10 $68.40 Total: $684.00
5 $80.75 Total: $403.75

Data sheet

Molecular FormulaC20H17N9
Molecular Weight383.42
CAS Numbers2127109-84-4
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymPF-06826647; PF 06826647; PF06826647; PF-6826647; PF 6826647; PF6826647; Tyk2-IN-8; Tyk2-IN 8; Tyk2-IN8;
IUPAC/Chemical Name(1r,3r)-3-(cyanomethyl)-3-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)-1H-pyrazol-1-yl)cyclobutane-1-carbonitrile
InChl KeyXPLZTJWZDBFWDE-OYOVHJISSA-N
InChl CodeInChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3/t14-,20-
SMILES CodeN#C[C@@H]1C[C@@](CC#N)(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5N=CC=C35)=C2)C1
References1) Brian S., et al., Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases, J. Med. Chem. 2020, 63, 22, 13561–13577

2) Miguel Nogueira, et al., JAK Inhibitors for Treatment of Psoriasis: Focus on Selective TYK2 Inhibitors, Drugs 2020 Mar;80(4):341-352

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Novel Selective Tyrosine Kinase 2 (TYK2) Inhibitor for the Treatment of Autoimmune Diseases

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