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View larger PF-04577806
AOB12520
CAS: 1072100-81-2
Chemical Name: N-[5-[(2S,5R)-2,5-Dimethyl-4-(oxan-4-ylmethyl)piperazine-1-carbonyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]pyridine-2-carboxamide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $109.65 | Total: $548.25 |
| 1 | 10 | $92.88 | Total: $928.80 |
| 1 | 25 | $78.69 | Total: $1,967.25 |
| 1 | 50 | $67.08 | Total: $3,354.00 |
| 1 | 100 | $58.05 | Total: $5,805.00 |
Data sheet
| Molecular Formula | C26H37N7O3 |
| Molecular Weight | 495.63 |
| CAS Numbers | 1072100-81-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | PF04577806; PF 04577806, R8068 |
| IUPAC/Chemical Name | N-[5-[(2S,5R)-2,5-Dimethyl-4-(oxan-4-ylmethyl)piperazine-1-carbonyl]-6,6-dimethyl-1,4-dihydropyrrolo[3,4-c]pyrazol-3-yl]pyridine-2-carboxamide |
| InChl Key | WIUOWTNXQICTJG-MSOLQXFVSA-N |
| InChl Code | InChI=1S/C26H37N7O3/c1-17-14-32(18(2)13-31(17)15-19-8-11-36-12-9-19)25(35)33-16-20-22(26(33,3)4)29-30-23(20)28-24(34)21-7-5-6-10-27-21/h5-7,10,17-19H,8-9,11-16H2,1-4H3,(H2,28,29,30,34)/t17-,18+/m1/s1 |
| SMILES Code | C[C@@H]1CN([C@@H](C)CN1CC2CCOCC2)C(=O)N3Cc4c(NC(=O)c5ccccn5)n[nH]c4C3(C)C |
| References | 1) Stephan Grant et al., Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model, European Journal of Pharmacology 637:16 (2010) |
More info
Novel inhibitor of protein kinase C (PKC), inhibiting PKC activity in retinal lysates from diabetic rats stimulated with phorbol myristate acetate