Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $62.90 | Total: $314.50 |
| 1 | 10 | $53.28 | Total: $532.80 |
| 1 | 25 | $45.14 | Total: $1,128.50 |
| 1 | 50 | $38.48 | Total: $1,924.00 |
| 1 | 100 | $33.30 | Total: $3,330.00 |
Overview
AAPK-25 is a potent and selective AuroraPLK dual inhibitor with anti-tumor activity, causing mitotic delay and arresting cells in prometaphase, followed by increased apoptosis. It targets Aurora-A-B-C with Kd values ranging from 23-289 nM.
Chemical Properties
| Molecular Formula | C21H13Cl2N3O2S |
| Molecular Weight | 442.32 |
| CAS Numbers | 2247919-28-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Clc1ccc(cc1Cl)C(=O)Nc1ccc2cc(ccc2c1)C(=O)Nc1nccs1 |
Storage and Handling
0C Short Term, -20C Long Term
References
Qi B, et al. Discovery of inhibitors of AuroraPLK targets as anti-cancer agents. J Med Chem. 2019 Aug 5.