Kinase Inhibitors

 OTS964 View larger

OTS964

AOB0644

CAS No: 1338545-07-5

 

Chemical Name: 9-[4-[(2R)-1-(Dimethylamino)propan-2-yl]phenyl]-8-hydroxy-5H-thieno[2,3-c]quinolin-4-one

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$25.00

$25.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.25 Total: $1,125.00
150 $13.00 Total: $650.00
125 $15.25 Total: $381.25
110 $18.00 Total: $180.00
15 $21.25 Total: $106.25

Data sheet

Molecular FormulaC23H25ClN2O2S
Molecular Weight428.97
CAS Numbers1338545-07-5
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymOTS964; OTS964; OTS 964; OTS964 HCl; OTS964 hydrochloride
IUPAC/Chemical Name(R)-9-(4-(1-(dimethylamino)propan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one hydrochloride
InChl Key YHPWOYBWUWSJDW-UQKRIMTDSA-N
InChl CodeInChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17-9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-;/m0./s1
SMILES Code[H]Cl.O=C1NC2=C(C(C3=CC=C([C@@H](C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC=C4
References1) Novel molecule targets cytokinesis. Cancer Discov. 2015 Jan;5(1):OF8. doi: 10.1158/2159-8290.CD-NB2014-170. Epub 2014 Nov 13. PubMed PMID: 25583820.

2) Matsuo Y, Park JH, Miyamoto T, Yamamoto S, Hisada S, Alachkar H, Nakamura Y. TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis. Sci Transl Med. 2014 Oct 22;6(259):259ra145. doi: 10.1126/scitranslmed.3010277. PubMed PMID: 25338756.

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Novel potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor

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