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ML381 (VU0488130) Fumarate
AOB2555
CAS No: 1623481-80-0 (free base)
Chemical Name: VU0488130; 5-[(3-Acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide fumarate
AOBIOUS launched this product in 2017
CITATIONS - Publications That Use AOBIOUS Product
1) Am J Physiol Gastrointest Liver Physiol 315: G473–G483 (2018)
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $30.15 | Total: $3,015.00 |
| 1 | 50 | $34.84 | Total: $1,742.00 |
| 1 | 25 | $40.87 | Total: $1,021.75 |
| 1 | 10 | $48.24 | Total: $482.40 |
| 1 | 5 | $56.95 | Total: $284.75 |
Data sheet
| Molecular Formula | C25H25N3O8 |
| Molecular Weight | 495.48 |
| CAS Numbers | 1623481-80-0 (Free Base) |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | ML381; ML 381; ML-381; VU0488130; VU-0488130; VU 0488130. |
| IUPAC/Chemical Name | 5-[(3-acetylphenoxy)methyl]-N-methyl-N-[(1S)-1-pyridin-2-ylethyl]-1,2-oxazole-3-carboxamide |
| InChl Key | JMYDHMCYZKRDPD-AWEZNQCLSA-N |
| InChl Code | InChI=1S/C21H21N3O4/c1-14(19-9-4-5-10-22-19)24(3)21(26)20-12-18(28-23-20)13-27-17-8-6-7-16(11-17)15(2)25/h4-12,14H,13H2,1-3H3/t14-/m0/s1 |
| SMILES Code | O=C(C1=NOC(COC2=CC=CC(C(C)=O)=C2)=C1)N(C)[C@H](C3=NC=CC=C3)C |
| References | 1) Gentry PR, etc. Development of a Novel, Orthosteric M5 Antagonist Possessing a High Degree of Muscarinic Subtype Selectivity. 2013 Dec 15 [updated 2015 Feb 11]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK280056/ PubMed PMID: 25834910. 2) Gentry PR, Kokubo M, Bridges TM, Cho HP, Smith E, Chase P, Hodder PS, Utley TJ, Rajapakse A, Byers F, Niswender CM, Morrison RD, Daniels JS, Wood MR, Conn PJ, Lindsley CW. Discovery, synthesis and characterization of a highly muscarinic acetylcholine receptor (mAChR)-selective M5-orthosteric antagonist, VU0488130 (ML381): a novel molecular probe. ChemMedChem. 2014 Aug;9(8):1677-82. |
More info
Highly Muscarinic Acetylcholine Receptor (mAChR)-Selective M5-Orthosteric Antagonist
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