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Neuropeptide Receptors
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View larger Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $54.40 | Total: $272.00 |
| 1 | 10 | $46.08 | Total: $460.80 |
| 1 | 25 | $39.04 | Total: $976.00 |
| 1 | 50 | $33.28 | Total: $1,664.00 |
| 1 | 100 | $28.80 | Total: $2,880.00 |
Data sheet
| Molecular Formula | C19H22BrClN2O5S |
| Molecular Weight | 505.81 |
| CAS Numbers | 474960-44-6 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | COc1cc(Br)c(cc1OC)S(=O)(=O)Nc1ccc(Cl)c(O[C@@H]2CCN(C)C2)c1 |
| References | Park SL, et al. Inhibitory Effect of an Urotensin II Receptor Antagonist on Proinflammatory Activation Inducedby Urotensin II in Human Vascular Endothelial Cells. Biomol Ther [Seoul]. 2013;21[4] 277-283. |
More info
SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.