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G140
AOB13353
CAS: 2369751-07-3
Chemical Name: 1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one
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| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $20.25 | Total: $2,025.00 |
| 1 | 50 | $23.40 | Total: $1,170.00 |
| 1 | 25 | $27.45 | Total: $686.25 |
| 1 | 10 | $32.40 | Total: $324.00 |
| 1 | 5 | $38.25 | Total: $191.25 |
Data sheet
| Molecular Formula | C17H16Cl2N4O2 |
| Molecular Weight | 379.24 |
| CAS Numbers | 2369751-07-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| IUPAC/Chemical Name | 1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl)-2-hydroxyethan-1-one |
| InChl Key | NVPFAXHXXODQRO-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3 |
| SMILES Code | O=C(N(C1)CCC(N2)=C1C3=C2C(Cl)=C(Cl)C=C3C4=NN(C)C=C4)CO |
| References | 1) Rhee SY, et al. A systematic review of the genetic mechanisms of dolutegravir resistance. J Antimicrob Chemother. 2019 Nov 1;74(11):3135-3149. doi: 10.1093/jac/dkz256. PubMed PMID: 31280314; PubMed Central PMCID: PMC6798839. 2) Ferrari D, et al. Increased dose of dolutegravir as a potential rescue therapy in multi-experienced patients. Antivir Ther. 2019;24(1):69-72. 3) Videlock EJ, Mahurkar-Joshi S, Hoffman JM, Iliopoulos D, Pothoulakis C, Mayer EA, Chang L. Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1;315(1):G140-G157 |
More info
Novel potent cGAS-specific inhibitor for repression of dsDNA-triggered interferon expression ( IC50 of 14 nM and 442 nM for h-cGAS and m-cGAS, respectively)
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