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V-11-0711
AOB14407
CAS: 1428339-47-2
Chemical Name: (1S)-1-phenyl-1-((1R,4R)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $44.55 | Total: $4,455.00 |
| 1 | 50 | $51.48 | Total: $2,574.00 |
| 1 | 25 | $60.39 | Total: $1,509.75 |
| 1 | 10 | $71.28 | Total: $712.80 |
| 1 | 5 | $84.15 | Total: $420.75 |
Data sheet
| Molecular Formula | C27H35NO3 |
| Molecular Weight | 421.58 |
| CAS Numbers | 1428339-47-2 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | V-11-0711; V11-0711; V 11-0711; V-110711; V110711; V 110711. |
| IUPAC/Chemical Name | (1S)-1-phenyl-1-((1R,4R)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol |
| InChl Key | XPPGCUMGAQHVOY-ZCJYOONXSA-N |
| InChl Code | InChI=1S/C27H35NO3/c29-27(23-7-2-1-3-8-23,25-20-28-16-11-21(25)12-17-28)15-10-22-6-4-5-9-26(22)31-24-13-18-30-19-14-24/h1-9,21,24-25,29H,10-20H2/t25?,27-/m1/s1 |
| SMILES Code | OC(C1C[N@]2CC[C@]1([H])CC2)(C3=CC=CC=C3)CCC4=CC=CC=C4OC5CCOCC5 |
| References | 1) Koch K, et al. Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget. 2016 Nov 8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. PubMed PMID: 27705917;PubMed Central PMCID: PMC5341988. 2) Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K, Bhujwalla ZM. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706. |
More info
A Chk-α inhibitor. V-11-0711 reduced the function of Chk-α by binding to the active site and inhibiting the catalytic activity but did not affect Chk-α protein levels. Chk-α protein and PtdCho, but not PC, may be essential in cancer cell proliferation.
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