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> Pathway Inhibitors>V-11-0711

Pathway Inhibitors

V-11-0711 View larger

V-11-0711

AOB14407

CAS: 1428339-47-2

 

Chemical Name: (1S)-1-phenyl-1-((1R,4R)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $84.15 Total: $420.75
110 $71.28 Total: $712.80
125 $60.39 Total: $1,509.75
150 $51.48 Total: $2,574.00
1100 $44.55 Total: $4,455.00

Data sheet

Molecular FormulaC27H35NO3
Molecular Weight421.58
CAS Numbers1428339-47-2
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymV-11-0711; V11-0711; V 11-0711; V-110711; V110711; V 110711.
IUPAC/Chemical Name(1S)-1-phenyl-1-((1R,4R)-quinuclidin-3-yl)-3-(2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)propan-1-ol
InChl KeyXPPGCUMGAQHVOY-ZCJYOONXSA-N
InChl CodeInChI=1S/C27H35NO3/c29-27(23-7-2-1-3-8-23,25-20-28-16-11-21(25)12-17-28)15-10-22-6-4-5-9-26(22)31-24-13-18-30-19-14-24/h1-9,21,24-25,29H,10-20H2/t25?,27-/m1/s1
SMILES CodeOC(C1C[N@]2CC[C@]1([H])CC2)(C3=CC=CC=C3)CCC4=CC=CC=C4OC5CCOCC5
References1) Koch K, et al. Reciprocal regulation of the cholinic phenotype and epithelial-mesenchymal transition in glioblastoma cells. Oncotarget. 2016 Nov 8;7(45):73414-73431. doi: 10.18632/oncotarget.12337. PubMed PMID: 27705917;PubMed Central PMCID: PMC5341988.

2) Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K, Bhujwalla ZM. Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival. NMR Biomed. 2015 Dec;28(12):1697-706.

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A Chk-α inhibitor. V-11-0711 reduced the function of Chk-α by binding to the active site and inhibiting the catalytic activity but did not affect Chk-α protein levels. Chk-α protein and PtdCho, but not PC, may be essential in cancer cell proliferation.

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