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> Pathway Inhibitors>K-975

Pathway Inhibitors

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K-975

AOB11890

CAS: 2563855-03-6

 

Chemical Name: N-(3-(4-Chlorophenoxy)-4-methylphenyl)acrylamide

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Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
15 $14.45 Total: $72.25
110 $12.24 Total: $122.40
125 $10.37 Total: $259.25
150 $8.84 Total: $442.00
1100 $7.65 Total: $765.00

Data sheet

Molecular FormulaC16H14ClNO2
Molecular Weight287.74
CAS Numbers2563855-03-6
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymK-975; K975; K 975;
IUPAC/Chemical NameN-(3-(4-chlorophenoxy)-4-methylphenyl)acrylamide
InChl KeyKPXAHQSIROUBPH-UHFFFAOYSA-N
InChl CodeInChI=1S/C16H14ClNO2/c1-3-16(19)18-13-7-4-11(2)15(10-13)20-14-8-5-12(17)6-9-14/h3-10H,1H2,2H3,(H,18,19)
SMILES CodeC=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O
References1) 1. Kaneda A, Seike T, Danjo T, Nakajima T, Otsubo N, Yamaguchi D, Tsuji Y, Hamaguchi K, Yasunaga M, Nishiya Y, Suzuki M, Saito JI, Yatsunami R, Nakamura S, Sekido Y, Mori K. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415. PMID: 33415007; PMCID: PMC7783735.

2) Lee S, Chung G, Kim J, Oh HB. Electron capture dissociation mass spectrometry of peptide cations containing a lysine homologue: a mobile proton model for explaining the observation of b-type product ions. Rapid Commun Mass Spectrom. 2006;20(21):3167-75. doi: 10.1002/rcm.2708. PMID: 17016809.

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First-in-class TEAD inhibitor, directly inhibiting YAP/TAZ-TEAD protein-protein interaction and showing a potent anti-tumor effect in malignant pleural mesothelioma