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SKI-178
AOB37162
CAS: 1259484-97-3
Chemical Name: N"-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $7.65 | Total: $765.00 |
| 1 | 50 | $8.84 | Total: $442.00 |
| 1 | 25 | $10.37 | Total: $259.25 |
| 1 | 10 | $12.24 | Total: $122.40 |
| 1 | 5 | $14.45 | Total: $72.25 |
Data sheet
| Molecular Formula | C21H22N4O4 |
| Molecular Weight | 394.4 |
| CAS Numbers | 1259484-97-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | SKI 178; SKI-178; SKI178 |
| IUPAC/Chemical Name | 3-(4-methoxyphenyl)-1H-pyrazole-5-carboxylic acid, 2-[1-(3,4-dimethoxyphenyl)ethylidene]hydrazide |
| InChl Key | GMFUWEBOUKIKRP-LPYMAVHISA-N |
| InChl Code | InChI=1S/C21H22N4O4/c1-13(15-7-10-19(28-3)20(11-15)29-4)22-25-21(26)18-12-17(23-24-18)14-5-8-16(27-2)9-6-14/h5-12H,1-4H3,(H,23,24)(H,25,26)/b22-13+ |
| SMILES Code | COC1=C(OC)C=CC(/C(C)=N/NC(C2=CC(C3=CC=C(OC)C=C3)=NN2)=O)=C1 |
| References | 1) Hengst, J.A., Dick, T.E., Sharma, A., et al. SKI-178: A multitargeted inhibitor of sphingosine kinase and microtubule dynamics demonstrating therapeutic efficacy in acute myeloid leukemia models. Cancer Transl. Med. 3(4), 109-121 (2017). 2) Hengst, J.A., Wang, X., Sk, U.H., et al. Development of a sphingosine kinase 1 specific small-molecule inhibitor. Bioorg. Med. Chem. Lett. 20(24), 7498-7502 (2010). |
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Novel Non-lipid inhibitor of sphingosine kinase 1 (SphK1)