Pathway Inhibitors

SHIN2 View larger

SHIN2

AOB11286

CAS: 2204289-53-0

 

Chemical Name: 6-Amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

AOBIOUS launched this product in 2018

CITATIONS - Publications That Use AOBIOUS Product

1) Cell Metabolism, V31(5), P920-936.E7, MAY 05, 2020

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$59.00

$59.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $26.55 Total: $2,655.00
150 $30.68 Total: $1,534.00
125 $35.99 Total: $899.75
110 $42.48 Total: $424.80
15 $50.15 Total: $250.75

Data sheet

Molecular FormulaC23H26N4O3
Molecular Weight406.49
CAS Numbers2204289-53-0
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymSHIN 2, SHIN-2
IUPAC/Chemical Name6-Amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
References1) Juan C. García-Cañaveras et. eal., SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia, Leukemia volume 35, pages377–388 (2021)

More info

Novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo

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