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View larger RMC-4550
AOB17380
CAS: 2172651-73-7
Chemical Name: (3-((3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl)methanol
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $31.45 | Total: $157.25 |
| 1 | 10 | $26.64 | Total: $266.40 |
| 1 | 25 | $22.57 | Total: $564.25 |
| 1 | 50 | $19.24 | Total: $962.00 |
| 1 | 100 | $16.65 | Total: $1,665.00 |
Data sheet
| Molecular Formula | C21H26Cl2N4O2 |
| Molecular Weight | 437.4 |
| CAS Numbers | 2172651-73-7 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | RMC-4550; RMC4550; RMC 4550. |
| IUPAC/Chemical Name | (3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl)methanol |
| InChl Key | IKUYEYLZXGGCRD-ORAYPTAESA-N |
| InChl Code | InChI=1S/C21H26Cl2N4O2/c1-12-18(14-4-3-5-15(22)17(14)23)26-16(10-28)20(25-12)27-8-6-21(7-9-27)11-29-13(2)19(21)24/h3-5,13,19,28H,6-11,24H2,1-2H3/t13-,19+/m0/s1 |
| SMILES Code | ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[C@@H](C)[C@H]4N)CC3)N=C2C)=CC=C1 |
| References | 1) Wang RR, et al., Probing the acting mode and advantages of RMC-4550 as an Src-homology 2 domain-containing protein tyrosine phosphatase (SHP2) inhibitor at molecular level through molecular docking and molecular dynamics. J Biomol Struct Dyn. 2019 May 1:1-14. doi: 10.1080/07391102.2019.1613266. [Epub ahead of print] PubMed PMID: 31043123. 2) Lee C, Rhee I. Important roles of protein tyrosine phosphatase PTPN12 in tumor progression. Pharmacol Res. 2019 Jun;144:73-78. doi: 10.1016/j.phrs.2019.04.011. Epub 2019 Apr 5. Review. PubMed PMID: 30959160. |
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Novel potent and selective SHP2 inhibitor
