Pathway Inhibitors

ML246 View larger

ML246 (Metarrestin)

AOB1384

CAS No: 1443414-10-5

 

Chemical Name: Metarrestin; trans-4-(7-benzyl-4-imino-5,6-diphenylpyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol

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$25.00

$25.00 per mg

Quantity Discount Table - Order More To Get More Price Discount

QuantitymgUnit Price ($/mg or $/Unit)Final Price
1100 $11.25 Total: $1,125.00
150 $13.00 Total: $650.00
125 $15.25 Total: $381.25
110 $18.00 Total: $180.00
15 $21.25 Total: $106.25

Data sheet

Molecular FormulaC31H30N4O
Molecular Weight474.6
CAS Numbers1443414-10-5
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
IUPAC/Chemical Nametrans-4-(7-benzyl-4-imino-5,6-diphenylpyrrolo[2,3-d]pyrimidin-3-yl)cyclohexan-1-ol
SMILES CodeO[C@H]1CC[C@H](N(C=NC2=C3C(C4=CC=CC=C4)=C(C5=CC=CC=C5) N2CC6=CC=CC=C6)C3=N)CC1
References1) Vilimas T, et al. Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer. Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080.

2) Frankowski KJ, et al. Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis. Sci Transl Med. 2018 May 16;10(441).

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Novel inhibitor of the perinucleolar compartment (PNC)

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