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Mivobulin isethionate (CI-980)
AOB15575
CAS: 126268-81-3
Chemical Name: CI-980; NSC-635370; Ethyl N-[(2S)-5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate 2-hydroxyethanesulfonic acid
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | 1 mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $40.05 | Total: $4,005.00 |
| 1 | 50 | $46.28 | Total: $2,314.00 |
| 1 | 25 | $54.29 | Total: $1,357.25 |
| 1 | 10 | $64.08 | Total: $640.80 |
| 1 | 5 | $75.65 | Total: $378.25 |
Data sheet
| Molecular Formula | C19H25N5O6S |
| Molecular Weight | 451.498 |
| CAS Numbers | 126268-81-3 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | Mivobulin Isethionate; CI-980; NSC-613863; NSC-635370; NSC-613862; NSC-350386; CI980; NSC613863; NSC635370; NSC613862; NSC350386. |
| IUPAC/Chemical Name | Ethyl (S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4-b)pyrazine-7-carbamate, mono(2-hydroxyethanesulfonate) |
| InChl Key | JEFPWOBULVSOTM-PPHPATTJSA-N |
| InChl Code | InChI=1S/C17H19N5O2.C2H6O4S/c1-3-24-17(23)21-13-9-12-15(16(18)20-13)22-14(10(2)19-12)11-7-5-4-6-8-11;3-1-2-7(4,5)6/h4-10,19H,3H2,1-2H3,(H3,18,20,21,23);3H,1-2H2,(H,4,5,6)/t10-;/m0./s1 |
| SMILES Code | O=C(OCC)NC1=CC2=C(C(N)=N1)N=C(C3=CC=CC=C3)[C@H](C)N2.OCCS(=O)(O)=O |
| References | 1) Kunschner LJ, Fine H, Hess K, Jaeckle K, Kyritsis AP, Yung WK. CI-980 for the treatment of recurrent or progressive malignant gliomas: national central nervous system consortium phase I-II evaluation of CI-980. Cancer Invest. 2002;20(7-8):948-54. PubMed PMID: 12449727. 2) Thomas JP, Moore T, Kraut EH, Balcerzak SP, Galloway S, Vandre DD; Ohio State University Phase II Research Consortium Study.. A phase II study of CI-980 in previously untreated extensive small cell lung cancer: an Ohio State University phase II research consortium study. Cancer Invest. 2002;20(2):192-8. PubMed PMID: 11901539. |
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Mitotic tubulin polymerization inhibitor, arresting cellular division by binding to the colchicine-binding site on tubulinn