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> Pathway Inhibitors>Mivobulin isethionate (CI-980)

Pathway Inhibitors

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Mivobulin isethionate (CI-980)

AOB15575

CAS: 126268-81-3

 

Chemical Name: CI-980; NSC-635370; Ethyl N-[(2S)-5-amino-2-methyl-3-phenyl-1,2-dihydropyrido[3,4-b]pyrazin-7-yl]carbamate 2-hydroxyethanesulfonic acid

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Quantity Discount Table - Order More To Get More Price Discount

Quantity1 mgUnit Price ($/mg or $/Unit)Final Price
15 $75.65 Total: $378.25
110 $64.08 Total: $640.80
125 $54.29 Total: $1,357.25
150 $46.28 Total: $2,314.00
1100 $40.05 Total: $4,005.00

Data sheet

Molecular FormulaC19H25N5O6S
Molecular Weight451.498
CAS Numbers126268-81-3
Storage Condition0°C (short term), -20°C (long term), desiccated
SolubilityDMSO
Purity98% by HPLC
SynonymMivobulin Isethionate; CI-980; NSC-613863; NSC-635370; NSC-613862; NSC-350386; CI980; NSC613863; NSC635370; NSC613862; NSC350386.
IUPAC/Chemical NameEthyl (S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido(3,4-b)pyrazine-7-carbamate, mono(2-hydroxyethanesulfonate)
InChl KeyJEFPWOBULVSOTM-PPHPATTJSA-N
InChl CodeInChI=1S/C17H19N5O2.C2H6O4S/c1-3-24-17(23)21-13-9-12-15(16(18)20-13)22-14(10(2)19-12)11-7-5-4-6-8-11;3-1-2-7(4,5)6/h4-10,19H,3H2,1-2H3,(H3,18,20,21,23);3H,1-2H2,(H,4,5,6)/t10-;/m0./s1
SMILES CodeO=C(OCC)NC1=CC2=C(C(N)=N1)N=C(C3=CC=CC=C3)[C@H](C)N2.OCCS(=O)(O)=O
References1) Kunschner LJ, Fine H, Hess K, Jaeckle K, Kyritsis AP, Yung WK. CI-980 for the treatment of recurrent or progressive malignant gliomas: national central nervous system consortium phase I-II evaluation of CI-980. Cancer Invest. 2002;20(7-8):948-54. PubMed PMID: 12449727.

2) Thomas JP, Moore T, Kraut EH, Balcerzak SP, Galloway S, Vandre DD; Ohio State University Phase II Research Consortium Study.. A phase II study of CI-980 in previously untreated extensive small cell lung cancer: an Ohio State University phase II research consortium study. Cancer Invest. 2002;20(2):192-8. PubMed PMID: 11901539.

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Mitotic tubulin polymerization inhibitor, arresting cellular division by binding to the colchicine-binding site on tubulinn