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View larger Sigma-1 receptor antagonist 3
AT12912
CAS 1639220-17-9
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $31.05 | Total: $3,105.00 |
| 1 | 50 | $35.88 | Total: $1,794.00 |
| 1 | 25 | $42.09 | Total: $1,052.25 |
| 1 | 10 | $49.68 | Total: $496.80 |
| 1 | 5 | $58.65 | Total: $293.25 |
Data sheet
| Molecular Formula | C19H23ClFN3O |
| Molecular Weight | 363.86 |
| CAS Numbers | 1639220-17-9 |
| Storage Condition | 0C Short Term, -20C Long Term |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | Cc1nc(nc(OCCCN2CCCCC2)c1Cl)-c1ccc(F)cc1 |
| References | Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57[24] 10404-23. |
More info
Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (?1) receptor (Ki = 1.14 nM) than ?2 receptor(Ki = 1239 nM). Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG, IC50 = 1.54 ?M)