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AP24534(Ponatinib)
AOB87302
CAS No:943319-70-8
AOBIOUS launched this product in 2015
CITATIONS - Publications That Use AOBIOUS Product
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Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 100 | $3.15 | Total: $315.00 |
| 1 | 50 | $3.64 | Total: $182.00 |
| 1 | 25 | $4.27 | Total: $106.75 |
| 1 | 10 | $5.04 | Total: $50.40 |
| 1 | 5 | $5.95 | Total: $29.75 |
Data sheet
| Molecular Formula | C29H27F3N6O |
| Molecular Weight | 532.56 |
| CAS Numbers | 943319-70-8 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| Synonym | AP24534; AP-24534; AP 24534; Ponatinib. Brand name: Iclusig. |
| IUPAC/Chemical Name | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide. |
| InChl Key | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39) |
| SMILES Code | O=C(NC1=CC=C(CN2CCN(C)CC2)C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3 |
| References | 1) Oaxaca DM, Yang-Reid SA, Ross JA, Rodriguez G, Staniswalis JG, Kirken RA. Sensitivity of imatinib-resistant T315I BCR-ABL CML to a synergistic combination of ponatinib and forskolin treatment. Tumour Biol. 2016 Jul 21. [Epub ahead of print] PubMed PMID: 27444277. 2) Dessilly G, Panin N, Elens L, Haufroid V, Demoulin JB. Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib. Sci Rep. 2016 Jul 12;6:29559. doi: 10.1038/srep29559. PubMed PMID: 27405085; PubMed Central PMCID: PMC4941718. |
More info
A novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src
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