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Cabozantinib (XL184, BMS-907351) Bulk
AOB87755
CAS No: 849217-68-1
Chemical Name: N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide
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Data sheet
| Molecular Formula | C28H24FN3O5 |
| Molecular Weight | 501.5 |
| CAS Numbers | 849217-68-1 |
| Storage Condition | 0°C (short term), -20°C (long term), desiccated |
| Solubility | DMF: 3 mg/ml DMSO: 5 mg/ml DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml Ethanol: 2 mg/ml |
| Purity | 98% by HPLC |
| Synonym | BMS-907351; BMS907351; Cabozantinib; XL184; XL-184 |
| IUPAC/Chemical Name | N'-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide |
| InChl Key | ONIQOQHATWINJY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34) |
| SMILES Code | COC1=C(OC)C=C(C(OC2=CC=C(NC(C3(C(NC4=CC=C(F)C=C4)=O)CC3)=O)C=C2)=CC=N5)C5=C1 |
| References | 1) Yakes, F.M., Chen, J., Tan, J., et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol. Cancer Ther. 10(12), 2298-2308 (2011). 2) Rausch, K., Hackett, B., Weinbren, N.R., S., et al. Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virus. Cell Rep. 18(3), 804-815 (2017). |
More info
A pan tyrosine kinase inhibitor that primarily targets VEGFR2 (IC50 = 0.035 nM) and c-Met (IC50 = 1.3 nM) but also inhibits RET, c-Kit, Axl, FLT3, and Tie2 (IC50s = 5.2, 4.6, 7, 11.3, and 14.3 nM, respectively).