Categories
- PROTAC Linker
- Protein Control Ligand
- Pathway Inhibitors
- Function Modulators
- Activators
- G Protein-Coupled Receptor Ligands
- Nuclear Receptor Ligands
- GDNF Receptors
- TNF Receptors
- Transcription Factors
- Chemokines
- Cytokine Receptors
- Biomarkers and Buffer Solutions
- Molecular Probes
- Stem Cell Research
- Alzheimer's Disease
- Apoptosis
- Cancer Research
- Epigenetics
- Metabolites
- PET/SPECT Imaging Precursors
- Customized Screening Library
- Ultra Pure Pharmacological Standard
- Tissue Microarray (TMA)
- Proteins and Antibodies
- Primary Cells
- ELISA KIT
- Natural Products
- Lab Equipments
- Humanized Mice for PDX Platform
- Rare Chemicals
- Custom Synthesis
- Antibacterial
- Antifungal
- Antioxidant
- Antiviral
- Molecular Glues
- SARS-CoV
Quantity Discount Table - Order More To Get More Price Discount
| Quantity | mg | Unit Price ($/mg or $/Unit) | Final Price |
|---|---|---|---|
| 1 | 5 | $353.60 | Total: $1,768.00 |
| 1 | 10 | $299.52 | Total: $2,995.20 |
| 1 | 25 | $253.76 | Total: $6,344.00 |
| 1 | 50 | $216.32 | Total: $10,816.00 |
| 1 | 100 | $187.20 | Total: $18,720.00 |
Overview
(Iso)-MS4322 ((Iso)-YS43-22) is a selective and potent protein arginine methyltransferase 5 (PRMT5) degrader with potential anticancer activity that effectively reduces PRMT5 protein levels in MCF-7 cells and inhibits the growth of a wide range of cancer cells.
Chemical Properties
| Molecular Formula | C55H76N10O12S |
| Molecular Weight | 1101.32 |
| CAS Numbers | 2601727-80-2 |
| Solubility | DMSO |
| Purity | 98% by HPLC |
| SMILES Code | C[C@@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](NC(=O)COCCOCCOCCOCCOCC(=O)N1CC(C1)Nc1cc(ncn1)C(=O)NC[C@H](O)CN1CCc2ccccc2C1)C(C)(C)C)c1ccc(cc1)-c1scnc1C |
Storage and Handling
0C Short Term, -20C Long Term
References
Shen Y, et al. Discovery of First-in-Class Protein Arginine Methyltransferase 5 [PRMT5] Degraders. J Med Chem. 2020 Sep 10;63[17] 9977-9989.